High mobility group box 1 protein as a marker of hepatocellular injury in human liver transplantation
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چکیده
منابع مشابه
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متن کاملHigh mobility group box protein-1 (HMGB-1) as a new diagnostic marker in patients with acute appendicitis
BACKGROUND The aim of this prospective study was therefore to evaluate the diagnostic value of preoperative serum High Mobility Group Box Protein-1 (HMGB-1) levels in patients with Acute Appendicitis (AA) who show normal white blood cell count (WBC) counts. METHOD Our study was carried out from October 2010 through November 2010 and included 20 healthy control group participants and 60 patien...
متن کاملHigh Mobility Group Box 1 and Traumatic Brain Injury
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. We identify High Mobility Group Box 1 (HMGB1) as a novel causative factor in the development of cerebral oedema, mediating coagulation, preventing secondary brain damage as well as serving as a novel therapeutic target to limit secondary neurological injury after TBI. As a prototypical danger associated molecular...
متن کاملHigh Mobility Group Box Protein-1 in Wound Repair
High-mobility group box 1 protein (HMGB1), a member of highly conserved non-histone DNA binding protein family, has been studied as transcription factor and growth factor. Secreted extracellularly by activated monocytes and macrophages or passively released by necrotic or damaged cells, extracellular HMGB1 is a potent mediator of inflammation. Extracellular HMGB1 has apparently contrasting biol...
متن کاملEvaluation of high mobility group box 1 protein as a presurgical diagnostic marker reflecting the severity of acute appendicitis
OBJECTIVES To validate the role of high mobility group box-1(HMGB1) in diagnosis of acute appendicitis (AA) with different pathological severity. METHODS According to the pathologically diagnosis, 150 patients underwent appendectomies between Jan. 2007 and Dec, 2010 were divided into acute simple, acute suppurative and acute gangrenous appendicitis as group 1, 2 and 3, respectively. Each pati...
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ژورنال
عنوان ژورنال: Liver Transplantation
سال: 2008
ISSN: 1527-6465
DOI: 10.1002/lt.21573